ECCN reference · Category 1: Special materials and related equipment, chemicals, microorganisms and toxins
ECCN 1C353
Genetic elements and genetically modified organisms, as follows
Materials. Reasons for control: CB (Chemical and biological weapons), AT (Anti-terrorism).
Does 1C353 need a license to your country?
Enter the full classification (for example 1C353.a.1) and a destination. The check reads the Country Chart, the end-use and embargo rules, and shows the rule and source behind the answer.
License requirements
Each control below comes from the entry’s License Requirements table. Where it names a Country Chart column, the countries with an X in that column need a license for the items the control covers, unless a License Exception applies.
- CB (Chemical and biological weapons): CB applies to genetic elements of items controlled by 1C351.d.15 and .16.
Country Chart column CB1: a license is needed to 196 countries with an X
Afghanistan, Albania, Algeria, Andorra, Angola, Antigua and Barbuda, Argentina, Armenia, Aruba, Australia, Austria, Azerbaijan, Bahamas, The, Bahrain, Bangladesh, Barbados, Belarus, Belgium, Belize, Benin, Bhutan, Bolivia, Bosnia and Herzegovina, Botswana, Brazil, Brunei, Bulgaria, Burkina Faso, Burma, Burundi, Cambodia, Cameroon, Canada, Cape Verde, Central African Republic, Chad, Chile, China, Colombia, Comoros, Congo (Democratic Republic of the), Congo (Republic of the), Costa Rica, Cote d'Ivoire, Croatia, Curaçao, Cyprus, Czech Republic, Denmark, Djibouti, Dominica, Dominican Republic, Ecuador, Egypt, El Salvador, Equatorial Guinea, Eritrea, Estonia, Eswatini, Ethiopia, Fiji, Finland, France, Gabon, Gambia, The, Georgia, Germany, Ghana, Greece, Grenada, Guatemala, Guinea, Guinea-Bissau, Guyana, Haiti, Honduras, Hungary, Iceland, India, Indonesia, Iraq, Ireland, Israel, Italy, Jamaica, Japan, Jordan, Kazakhstan, Kenya, Kiribati, Korea, South, Kosovo, Kuwait, Kyrgyzstan, Laos, Latvia, Lebanon, Lesotho, Liberia, Libya, Liechtenstein, Lithuania, Luxembourg, Macau, Madagascar, Malawi, Malaysia, Maldives, Mali, Malta, Marshall Islands, Mauritania, Mauritius, Mexico, Micronesia (Federated State of), Moldova, Monaco, Mongolia, Montenegro, Morocco, Mozambique, Namibia, Nauru, Nepal, Netherlands, New Zealand, Nicaragua, Niger, Nigeria, North Macedonia, Norway, Oman, Pakistan, Palau, Panama, Papua New Guinea, Paraguay, Peru, Philippines, Poland, Portugal, Qatar, Romania, Russia, Rwanda, Samoa, San Marino, Sao Tome and Principe, Saudi Arabia, Senegal, Serbia, Seychelles, Sierra Leone, Singapore, Sint Maarten (the Dutch two-fifths of the island of Saint Martin), Slovakia, Slovenia, Solomon Islands, Somalia, South Africa, South Sudan, Republic of, Spain, Sri Lanka, St. Kitts and Nevis, St. Lucia, St. Vincent and the Grenadines, Sudan, Suriname, Sweden, Switzerland, Taiwan, Tajikistan, Tanzania, Thailand, Timor-Leste, Togo, Tonga, Trinidad and Tobago, Tunisia, Turkmenistan, Tuvalu, Türkiye, Uganda, Ukraine, United Arab Emirates, United Kingdom, Uruguay, Uzbekistan, Vanuatu, Vatican City, Venezuela, Vietnam, Western Sahara, Yemen, Zambia, Zimbabwe.
- CB (Chemical and biological weapons): CB applies to entire entry.
Country Chart column CB2: a license is needed to 154 countries with an X
Afghanistan, Albania, Algeria, Andorra, Angola, Antigua and Barbuda, Armenia, Aruba, Azerbaijan, Bahamas, The, Bahrain, Bangladesh, Barbados, Belarus, Belize, Benin, Bhutan, Bolivia, Bosnia and Herzegovina, Botswana, Brazil, Brunei, Burkina Faso, Burma, Burundi, Cambodia, Cameroon, Cape Verde, Central African Republic, Chad, Chile, China, Colombia, Comoros, Congo (Democratic Republic of the), Congo (Republic of the), Costa Rica, Cote d'Ivoire, Curaçao, Djibouti, Dominica, Dominican Republic, Ecuador, Egypt, El Salvador, Equatorial Guinea, Eritrea, Eswatini, Ethiopia, Fiji, Gabon, Gambia, The, Georgia, Ghana, Grenada, Guatemala, Guinea, Guinea-Bissau, Guyana, Haiti, Honduras, Indonesia, Iraq, Israel, Jamaica, Jordan, Kazakhstan, Kenya, Kiribati, Kosovo, Kuwait, Kyrgyzstan, Laos, Lebanon, Lesotho, Liberia, Libya, Macau, Madagascar, Malawi, Malaysia, Maldives, Mali, Marshall Islands, Mauritania, Mauritius, Micronesia (Federated State of), Moldova, Monaco, Mongolia, Montenegro, Morocco, Mozambique, Namibia, Nauru, Nepal, Nicaragua, Niger, Nigeria, North Macedonia, Oman, Pakistan, Palau, Panama, Papua New Guinea, Paraguay, Peru, Philippines, Qatar, Russia, Rwanda, Samoa, San Marino, Sao Tome and Principe, Saudi Arabia, Senegal, Serbia, Seychelles, Sierra Leone, Singapore, Sint Maarten (the Dutch two-fifths of the island of Saint Martin), Solomon Islands, Somalia, South Africa, South Sudan, Republic of, Sri Lanka, St. Kitts and Nevis, St. Lucia, St. Vincent and the Grenadines, Sudan, Suriname, Taiwan, Tajikistan, Tanzania, Thailand, Timor-Leste, Togo, Tonga, Trinidad and Tobago, Tunisia, Turkmenistan, Tuvalu, Uganda, United Arab Emirates, Uruguay, Uzbekistan, Vanuatu, Vatican City, Venezuela, Vietnam, Western Sahara, Yemen, Zambia, Zimbabwe.
- AT (Anti-terrorism): AT applies to entire entry. No Country Chart country has an X in column AT1; the destinations this control targets are under “Not decided by the Country Chart” below.
Not decided by the Country Chart: Covered Donetsk region of Ukraine (DNR), Covered Luhansk region of Ukraine (LNR), Crimea region of Ukraine, Cuba, Iran, Korea, North, Syria. These destinations are under embargoes or other special controls in 15 CFR Part 746, which require a license for most items whatever the chart shows. Russia and Belarus also have broad Part 746 controls in addition to the chart.
A blank on the Country Chart is not permission to ship. End-use and end-user rules (15 CFR Part 744), embargoes and sanctions (Part 746), and the parties to the transaction still apply. Use the check above for your item and country.
List-based License Exceptions
As the entry lists them. Each exception has its own conditions in 15 CFR Part 740, and § 740.2 bars or limits most of them for Russia, Belarus, Country Group D:5 and embargoed destinations, so an entry’s “Yes” does not mean it is available everywhere.
- LVS: N/A
- GBS: N/A
Items in 1C353
The controls often apply to some paragraphs only, so check the full paragraph, for example 1C353.a.
Show all 6 paragraphs
- 1C353.a Any genetically modified organism that contains, or any genetic element that codes for, any of the following:
- 1C353.a.1 Any gene, genes, translated product or translated products specific to any virus controlled by 1C351.a or .b or 1C354.c;
- 1C353.a.2 Any gene or genes specific to any bacterium controlled by 1C351.c or 1C354.a, or any fungus controlled by 1C351.e or 1C354.b, and which;
- 1C353.a.2.a In itself or through its transcribed or translated products represents a significant hazard to human, animal or plant health; or
- 1C353.a.2.b Could endow or enhance pathogenicity; or
- 1C353.a.3 Any toxins, or their subunits, controlled by 1C351.d.
Source
Commerce Control List, 15 CFR Part 774, Supplement No. 1 (official text on eCFR), as of August 21, 2026, 1:45AM EDT. Commerce Country Chart, Supplement No. 1 to Part 738, as of August 21, 2026, 1:45AM EDT.
This page is a preliminary reference, not legal advice, a classification ruling or permission to ship. Confirm the classification against the full official text.