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ECCN reference · Category 2: Materials processing

ECCN 2B352

Equipment Capable of Use in Handling Biological Materials, as Follows

Test, inspection and production equipment. Reasons for control: CB (Chemical and biological weapons), AT (Anti-terrorism).

Does 2B352 need a license to your country?

Enter the full classification (for example 2B352.a.1) and a destination. The check reads the Country Chart, the end-use and embargo rules, and shows the rule and source behind the answer.

License requirement check

Item classification and destination. No account needed.

An ECCN (such as 5A992.c) is an exact match and works best. Word search matches the official CCL wording and a reviewed list of everyday names as you write them; it does not guess what you mean or fix spelling. Don’t know the ECCN? Use Find the ECCN.

License requirements

Each control below comes from the entry’s License Requirements table. Where it names a Country Chart column, the countries with an X in that column need a license for the items the control covers, unless a License Exception applies.

  • CB (Chemical and biological weapons): CB applies to entire entry.
    Country Chart column CB2: a license is needed to 154 countries with an X

    Afghanistan, Albania, Algeria, Andorra, Angola, Antigua and Barbuda, Armenia, Aruba, Azerbaijan, Bahamas, The, Bahrain, Bangladesh, Barbados, Belarus, Belize, Benin, Bhutan, Bolivia, Bosnia and Herzegovina, Botswana, Brazil, Brunei, Burkina Faso, Burma, Burundi, Cambodia, Cameroon, Cape Verde, Central African Republic, Chad, Chile, China, Colombia, Comoros, Congo (Democratic Republic of the), Congo (Republic of the), Costa Rica, Cote d'Ivoire, Curaçao, Djibouti, Dominica, Dominican Republic, Ecuador, Egypt, El Salvador, Equatorial Guinea, Eritrea, Eswatini, Ethiopia, Fiji, Gabon, Gambia, The, Georgia, Ghana, Grenada, Guatemala, Guinea, Guinea-Bissau, Guyana, Haiti, Honduras, Indonesia, Iraq, Israel, Jamaica, Jordan, Kazakhstan, Kenya, Kiribati, Kosovo, Kuwait, Kyrgyzstan, Laos, Lebanon, Lesotho, Liberia, Libya, Macau, Madagascar, Malawi, Malaysia, Maldives, Mali, Marshall Islands, Mauritania, Mauritius, Micronesia (Federated State of), Moldova, Monaco, Mongolia, Montenegro, Morocco, Mozambique, Namibia, Nauru, Nepal, Nicaragua, Niger, Nigeria, North Macedonia, Oman, Pakistan, Palau, Panama, Papua New Guinea, Paraguay, Peru, Philippines, Qatar, Russia, Rwanda, Samoa, San Marino, Sao Tome and Principe, Saudi Arabia, Senegal, Serbia, Seychelles, Sierra Leone, Singapore, Sint Maarten (the Dutch two-fifths of the island of Saint Martin), Solomon Islands, Somalia, South Africa, South Sudan, Republic of, Sri Lanka, St. Kitts and Nevis, St. Lucia, St. Vincent and the Grenadines, Sudan, Suriname, Taiwan, Tajikistan, Tanzania, Thailand, Timor-Leste, Togo, Tonga, Trinidad and Tobago, Tunisia, Turkmenistan, Tuvalu, Uganda, United Arab Emirates, Uruguay, Uzbekistan, Vanuatu, Vatican City, Venezuela, Vietnam, Western Sahara, Yemen, Zambia, Zimbabwe.

  • AT (Anti-terrorism): AT applies to entire entry. No Country Chart country has an X in column AT1; the destinations this control targets are under “Not decided by the Country Chart” below.

Not decided by the Country Chart: Covered Donetsk region of Ukraine (DNR), Covered Luhansk region of Ukraine (LNR), Crimea region of Ukraine, Cuba, Iran, Korea, North, Syria. These destinations are under embargoes or other special controls in 15 CFR Part 746, which require a license for most items whatever the chart shows. Russia and Belarus also have broad Part 746 controls in addition to the chart.

A blank on the Country Chart is not permission to ship. End-use and end-user rules (15 CFR Part 744), embargoes and sanctions (Part 746), and the parties to the transaction still apply. Use the check above for your item and country.

List-based License Exceptions

As the entry lists them. Each exception has its own conditions in 15 CFR Part 740, and § 740.2 bars or limits most of them for Russia, Belarus, Country Group D:5 and embargoed destinations, so an entry’s “Yes” does not mean it is available everywhere.

  • LVS: N/A
  • GBS: N/A

Items in 2B352

The controls often apply to some paragraphs only, so check the full paragraph, for example 2B352.a.

Show all 50 paragraphs
  • 2B352.a Containment facilities and related equipment, as follows:
  • 2B352.a.1 Complete containment facilities at P3 or P4 containment level.
  • 2B352.a.2 Equipment designed for fixed installation in containment facilities specified in paragraph a.1 of this ECCN, as follows:
  • 2B352.a.2.a Double-door pass-through decontamination autoclaves;
  • 2B352.a.2.b Breathing air suit decontamination showers;
  • 2B352.a.2.c Mechanical-seal or inflatable-seal walkthrough doors.
  • 2B352.b Fermenters and components as follows:
  • 2B352.b.1 Fermenters capable of cultivation of micro-organisms or of live cells for the production of viruses or toxins, without the propagation of aerosols, having a total internal volume of 20 liters or greater.
  • 2B352.b.2 Components designed for such fermenters, as follows:
  • 2B352.b.2.a Cultivation chambers designed to be sterilized or disinfected in situ;
  • 2B352.b.2.b Cultivation chamber holding devices; or
  • 2B352.b.2.c Process control units capable of simultaneously monitoring and controlling two or more fermentation system parameters (e.g., temperature, pH, nutrients, agitation, dissolved oxygen, air flow, foam control).
  • 2B352.c Centrifugal separators capable of continuous separation, without the propagation of aerosols, having a flow rate greater than 100 liters per hour, as follows:
  • 2B352.c.1 Centrifugal separators having all of the following characteristics:
  • 2B352.c.1.a One or more sealing joints within the steam containment area;
  • 2B352.c.1.b Components of polished stainless steel or titanium; and
  • 2B352.c.1.c Capable of in-situ steam sterilization in a closed state.
  • 2B352.c.2 Single-use centrifugal separators, in which all components that come in direct contact with the substances being processed are disposable or single-use.
  • 2B352.d Cross (tangential) flow filtration equipment and "accessories", as follows:
  • 2B352.d.1 Cross (tangential) flow filtration equipment capable of separation of microorganisms, viruses, toxins or cell cultures having all of the following characteristics:
  • 2B352.d.1.a A total filtration area equal to or greater than 1 square meter (1 m^2); and
  • 2B352.d.1.b Having any of the following characteristics:
  • 2B352.d.1.b.1 Capable of being sterilized or disinfected in-situ; or
  • 2B352.d.1.b.2 Using disposable or single-use filtration "parts" or "components".
  • 2B352.d.2 Cross (tangential) flow filtration "parts" or "components" (e.g., modules, elements, cassettes, cartridges, units or plates) with filtration area equal to or greater than 0.2 square meters (0.2 m^2) for each "part" or "component" and designed for use in cross (tangential) flow filtration equipment controlled by 2B352.d.1.
  • 2B352.e Steam, gas or vapor sterilizable freeze-drying equipment with a condenser capacity of 10 kg of ice or greater in 24 hours (10 liters of water or greater in 24 hours) and less than 1000 kg of ice in 24 hours (less than 1,000 liters of water in 24 hours).
  • 2B352.f Spray-drying equipment capable of drying toxins or pathogenic microorganisms having all of the following characteristics:
  • 2B352.f.1 A water evaporation capacity of ≥0.4 kg/h and ≤400 kg/h;
  • 2B352.f.2 The ability to generate a typical mean product particle size of ≤10 micrometers with existing fittings or by minimal modification of the spray-dryer with atomization nozzles enabling generation of the required particle size; and
  • 2B352.f.3 Capable of being sterilized or disinfected in situ.
  • 2B352.g Protective and containment equipment, as follows:
  • 2B352.g.1 Protective full or half suits, or hoods dependent upon a tethered external air supply and operating under positive pressure.
  • 2B352.g.2 Biocontainment chambers, isolators, or biological safety cabinets having all of the following characteristics, for normal operation:
  • 2B352.g.2.a Fully enclosed workspace where the operator is separated from the work by a physical barrier;
  • 2B352.g.2.b Able to operate at negative pressure;
  • 2B352.g.2.c Means to safely manipulate items in the workspace; and
  • 2B352.g.2.d Supply and exhaust air to and from the workspace is high-efficiency particulate air (HEPA) filtered.
  • 2B352.h Aerosol inhalation equipment designed for aerosol challenge testing with microorganisms, viruses or toxins, as follows:
  • 2B352.h.1 Whole-body exposure chambers having a capacity of 1 cubic meter or greater;
  • 2B352.h.2 Nose-only exposure apparatus utilizing directed aerosol flow and having a capacity for the exposure of 12 or more rodents, or two or more animals other than rodents, and closed animal restraint tubes designed for use with such apparatus.
  • 2B352.i Spraying or fogging systems and "parts" and "components" therefor, as follows:
  • 2B352.i.1 Complete spraying or fogging systems, "specially designed" or modified for fitting to aircraft, "lighter than air vehicles," or "UAVs," capable of delivering, from a liquid suspension, an initial droplet "VMD" of less than 50 microns at a flow rate of greater than 2 liters per minute;
  • 2B352.i.2 Spray booms or arrays of aerosol generating units, "specially designed" or modified for fitting to aircraft, "lighter than air vehicles," or "UAVs," capable of delivering, from a liquid suspension, an initial droplet "VMD" of less than 50 microns at a flow rate of greater than 2 liters per minute;
  • 2B352.i.3 Aerosol generating units "specially designed" for fitting to the systems as specified in paragraphs i.1 and i.2 of this ECCN.
  • 2B352.j Nucleic acid assemblers and synthesizers that are both:
  • 2B352.j.1 Partly or entirely automated; and
  • 2B352.j.2 Designed to generate continuous nucleic acids greater than 1.5 kilobases in length with error rates less than 5% in a single run.
  • 2B352.k Peptide synthesizers that are both:
  • 2B352.k.1 Partly or entirely automated; and
  • 2B352.k.2 Capable of generating peptides at a 'system synthesis scale' of 1 mmol or greater.

Source

Commerce Control List, 15 CFR Part 774, Supplement No. 1 (official text on eCFR), as of August 21, 2026, 1:45AM EDT. Commerce Country Chart, Supplement No. 1 to Part 738, as of August 21, 2026, 1:45AM EDT.

This page is a preliminary reference, not legal advice, a classification ruling or permission to ship. Confirm the classification against the full official text.